Immune Support, Training and EnergySpike Protein Research
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Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell, functioning as a central electron carrier in metabolic reactions and as a substrate for several classes of enzymes. It is studied for its roles in cellular energy production, DNA repair signaling, sirtuin pathway activation, and the regulation of aging-related cellular processes. NAD+ levels naturally decline with age, making it a subject of significant longevity research.
Forschungsbereiche
Sirtuin Activation & Longevity SignalingResearch investigates NAD+'s role as a required substrate for sirtuin enzymes (SIRT1–7), exploring how sirtuin activation affects gene expression regulation, mitochondrial biogenesis signaling, and aging-related pathway research.
DNA Repair & PARP SignalingStudies examine NAD+'s role as a substrate for poly(ADP-ribose) polymerase (PARP) enzymes, which are central to DNA strand break repair signaling and genomic stability maintenance pathway research.
Cellular Energy Metabolism ResearchResearchers study NAD+/NADH cycling in glycolysis, the citric acid cycle, and oxidative phosphorylation, investigating how NAD+ availability affects mitochondrial ATP production signaling and cellular energy homeostasis.
Mitochondrial Function Pathway ResearchStudies explore NAD+'s role in mitochondrial biogenesis signaling via PGC-1α pathway activation, electron transport chain function research, and mitochondrial quality control pathway investigations.
Circadian Clock Signaling ResearchResearch investigates the reciprocal relationship between NAD+ metabolism and circadian clock machinery, including NAMPT-driven NAD+ biosynthesis rhythm research and its effects on clock gene signaling pathways.
Neurological & Neuroprotective Pathway ResearchStudies examine NAD+'s role in neuronal energy metabolism, axonal integrity signaling (via SARM1 pathway research), and its potential neuroprotective effects in neurodegeneration-related signaling investigations.